Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice
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چکیده
منابع مشابه
Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice
The ALK (Anaplastic Lymphoma Kinase) gene encodes a tyrosine kinase receptor preferentially expressed in the central and peripheral nervous systems. A syndromic presentation associating congenital neuroblastoma with severe encephalopathy and an abnormal shape of the brainstem has been described in patients harbouring de novo germline F1174V and F1245V ALK mutations. Here, we investigated the ph...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2014
ISSN: 1949-2553
DOI: 10.18632/oncotarget.1882